We study how metabolites regulate cellular communication within the liver microenvironment. Our research focuses on metabolite-driven interactions among hepatocytes and non-parenchymal cells, including hepatic stellate cells and Kupffer cells.

We are also interested in the metabolite-mediated gut-liver axis as a central pathway linking microbial metabolism, hepatic products, and liver function.

  By studying these bidirectional metabolic networks, we seek to understand how liver physiology is coordinated across tissues and cell types. We investigate how these processes are remodeled in diverse contexts, including homeostasis, inflammation, fibrosis, and metabolic liver disease. Ultimately, our goal is to define fundamental mechanisms of hepatic metabolic coordination and identify new therapeutic opportunities.